Beaumont was the ninth high school to be open in the St. Louis Public School System in September of 1926 and was named for the early St. Louis surgeon Dr. William Beaumont. Beaumont High School stands on the former site of National League park, where the St. Louis Cardinals played from 1899 until their move to Sportsman's Park on Grand Boulevard in 1920. The city bought the ballpark in 1920 and six years later, built the largest school in St. Louis. The cost to build the school was the most of the previous eight at $2,296.870 including the site. It contained 95 rooms, besides 30 ancillary rooms, and an auditorium seating 2,250 people. Its site was 6351/2 feet by 672 feet.

Beaumont High School inherited the legacy of twenty years of rich experience of the Yeatman High School. When it opened, the entire student body and faculty of the Yeatman High School moved from their old building to the larger Beaumont High in 1926. The students from the ninth grade of the Central High School also moved there. Those two bodies of students were fused into one homogeneous group destined to build a new spiritual superstructure upon the foundation provided by former experiences.

The first Principal was Mr. Wilbur N. Fuller and Mr. Albert H. Huntington was the assistant principal.

The school, which serves fourteen hundred students, recently reopened following a complete renovation. Beaumont High School has received local, state and national awards for its science programs.